Jun 4 Sat 2022
| 01:05 PM | ||||
| 967 | Detroit TigersB. Brieske -R | +1½ +110 | +245 | O 8 -125 |
| 968 | New York YankeesL. Severino -R | -1½ -130 | -275 | U 8 +105 |
| 03:07 PM | ||||
| 969 | Minnesota TwinsD. Bundy -R | +1½ -145 | +141 | O 9 -115 |
| 970 | Toronto Blue JaysJ. Berrios -R | -1½ +125 | -153 | U 9 -105 |
| 04:05 PM | ||||
| 953 | Arizona DiamondbacksZ. Davies -R | +1½ -190 | +115 | O 8½ -115 |
| 954 | Pittsburgh PiratesR. Contreras -R | -1½ +165 | -125 | U 8½ -105 |
| 04:05 PM | ||||
| 971 | Seattle MarinersM. Gonzales -L | +1½ -190 | +107 | O 8½ -120 |
| 972 | Texas RangersG. Otto -R | -1½ +165 | -117 | U 8½ +100 |
| 04:05 PM | ||||
| 973 | Cleveland GuardiansT. McKenzie -R | -1½ +135 | -123 | O 8½ +105 |
| 974 | Baltimore OriolesT. Wells -R | +1½ -155 | +113 | U 8½ -125 |
| 04:07 PM | ||||
| 975 | Boston Red SoxN. Pivetta -R | -1½ +140 | -125 | O 7½ +100 |
| 976 | Oakland AthleticsP. Blackburn -R | +1½ -160 | +115 | U 7½ -120 |
| 04:10 PM | ||||
| 955 | Washington NationalsE. Fedde -R | +1½ -160 | +125 | O 9½ -115 |
| 956 | Cincinnati RedsT. Mahle -R | -1½ +140 | -135 | U 9½ -105 |
| 04:10 PM | ||||
| 957 | San Diego PadresM. Gore -L | +1½ -190 | +110 | O 7½ -110 |
| 958 | Milwaukee BrewersA. Ashby -L | -1½ +165 | -120 | U 7½ -110 |
| 04:10 PM | ||||
| 959 | San Francisco GiantsL. Webb -R | -1½ +155 | -105 | O 7 +110 |
| 960 | Miami MarlinsP. Lopez -R | +1½ -175 | -105 | U 7 -130 |
| 04:10 PM | ||||
| 977 | Chicago White SoxD. Cease -R | +1½ -205 | +104 | O 7 +100 |
| 978 | Tampa Bay RaysD. Rasmussen -R | -1½ +175 | -114 | U 7 -120 |
| 09:10 PM | ||||
| 963 | Atlanta BravesS. Strider -R | -1½ +100 | -151 | O 11½ -120 |
| 964 | Colorado RockiesK. Freeland -L | +1½ -120 | +139 | U 11½ +100 |
| 10:10 PM | ||||
| 965 | New York MetsD. Peterson -L | +1½ -130 | +161 | O 8½ -120 |
| 966 | Los Angeles DodgersW. Buehler -R | -1½ +110 | -175 | U 8½ +100 |
