Apr 16 Sat 2022
| 12:10 PM | ||||
| 901 | Arizona DiamondbacksZ. Gallen -R | +1½ -140 | +146 | O 8 -105 |
| 902 | New York MetsC. Carrasco -R+1 Markets | -1½ +120 | -158 | U 8 -115 |
| 01:10 PM | ||||
| 915 | Tampa Bay RaysC. Kluber -R | +1½ -170 | +120 | O 8½ -112 |
| 916 | Chicago White SoxM. Kopech -R+1 Markets | -1½ +150 | -130 | U 8½ -108 |
| 02:07 PM | ||||
| 917 | Oakland AthleticsP. Blackburn -R | +1½ -110 | +196 | O 9 -105 |
| 918 | Toronto Blue JaysH. Ryu -L+1 Markets | -1½ -110 | -215 | U 9 -115 |
| 03:05 PM | ||||
| 903 | Atlanta BravesI. Anderson -R | +1½ -215 | -110 | O 8½ +105 |
| 904 | San Diego PadresN. Martinez -R+1 Markets | -1½ +185 | +100 | U 8½ -125 |
| 03:10 PM | ||||
| 919 | Minnesota TwinsS. Gray -R | +1½ -170 | +110 | O 9½ -105 |
| 920 | Boston Red SoxT. Houck -R+1 Markets | -1½ +150 | -120 | U 9½ -115 |
| 03:10 PM | ||||
| 921 | Detroit TigersM. Manning -R | +1½ -180 | +108 | O 9 +105 |
| 922 | Kansas City RoyalsK. Bubic -L+1 Markets | -1½ +160 | -118 | U 9 -125 |
| 05:10 PM | ||||
| 905 | Philadelphia PhilliesR. Suarez -L | +1½ -220 | -110 | O 8 +100 |
| 906 | Miami MarlinsT. Rogers -L+1 Markets | -1½ +190 | +100 | U 8 -120 |
| 05:10 PM | ||||
| 929 | San Francisco GiantsA. DeSclafani -R | -1½ +135 | -114 | O 8 -110 |
| 930 | Cleveland GuardiansC. Quantrill -R+1 Markets | +1½ -155 | +104 | U 8 -110 |
| 05:35 PM | ||||
| 907 | Washington NationalsJ. Rogers -L | -1½ +155 | +105 | O 9 -120 |
| 908 | Pittsburgh PiratesB. Wilson -R+1 Markets | +1½ -175 | -115 | U 9 +100 |
| 06:05 PM | ||||
| 923 | Los Angeles AngelsN. Syndergaard -R | -1½ +120 | -120 | O 9 -115 |
| 924 | Texas RangersT. Hearn -L+1 Markets | +1½ -140 | +110 | U 9 -105 |
| 06:05 PM | ||||
| 925 | New York YankeesJ. Taillon -R | -1½ -110 | -175 | O 9 -110 |
| 926 | Baltimore OriolesT. Wells -R+1 Markets | +1½ -110 | +161 | U 9 -110 |
| 06:10 PM | ||||
| 909 | St. Louis CardinalsS. Matz -L | +1½ -190 | -102 | O 8½ -110 |
| 910 | Milwaukee BrewersA. Houser -R+1 Markets | -1½ +165 | -108 | U 8½ -110 |
| 07:10 PM | ||||
| 911 | Chicago Cubs | +120 | O 12 -104 | |
| 912 | Colorado Rockies+1 Markets | -130 | U 12 -116 |
| 08:10 PM | ||||
| 927 | Houston AstrosJ. Verlander -R | -1½ +100 | -146 | O 7½ -110 |
| 928 | Seattle MarinersC. Flexen -R+1 Markets | +1½ -120 | +135 | U 7½ -110 |
| 09:10 PM | ||||
| 913 | Cincinnati RedsH. Greene -R | +1½ +107 | +204 | O 9 -103 |
| 914 | Los Angeles DodgersJ. Urias -L+1 Markets | -1½ -127 | -225 | U 9 -117 |