Aug 28 Sat 2021
| 3:05 PM | ||||
| 963 | Boston Red SoxN. Eovaldi -R | -150 | O 9½ -110 | |
| 964 | Cleveland IndiansC. Quantrill -R | +139 | U 9½ -110 |
| 3:07 PM | ||||
| 965 | New York YankeesN. Cortes -L | -114 | O 8½ -120 | |
| 966 | Oakland AthleticsF. Montas -R | +104 | U 8½ +100 |
| 3:10 PM | ||||
| 967 | Kansas City RoyalsC. Hernandez -R | +137 | O 8½ -120 | |
| 968 | Seattle MarinersT. Anderson -L | -148 | U 8½ +100 |
| 5:05 PM | ||||
| 951 | Arizona DiamondbacksH. Mejia -R | +189 | O 9 +105 | |
| 952 | Philadelphia PhilliesK. Gibson -R | -207 | U 9 -125 |
| 5:10 PM | ||||
| 953 | Cincinnati RedsV. Gutierrez -R | -114 | O 8 +100 | |
| 954 | Miami MarlinsS. Alcantara -R | +104 | U 8 -120 |
| 6:05 PM | ||||
| 955 | St. Louis CardinalsA. Wainwright -R | -173 | O 8½ +105 | |
| 956 | Pittsburgh PiratesS. Brault -L | +159 | U 8½ -125 |
| 6:05 PM | ||||
| 973 | Houston AstrosF. Valdez -L | -230 | O 9 -105 | |
| 974 | Texas RangersK. Allard -L | +208 | U 9 -115 |
| 6:10 PM | ||||
| 957 | Washington NationalsS. Nolin -L | +193 | O 8½ -105 | |
| 958 | New York MetsM. Stroman -R | -211 | U 8½ -115 |
| 6:10 PM | ||||
| 975 | Chicago CubsA. Mills -R | +245 | O 8½ -120 | |
| 976 | Chicago White SoxL. Lynn -R | -275 | U 8½ +100 |
| 6:10 PM | ||||
| 977 | Milwaukee BrewersA. Houser -R | -140 | O 9½ -130 | |
| 978 | Minnesota TwinsC. Barnes -L | +130 | U 9½ +110 |
| 8:10 PM | ||||
| 961 | Colorado RockiesJ. Gray -R | +224 | O 8½ -125 | |
| 962 | Los Angeles DodgersD. Price -L | -250 | U 8½ +105 |
