Aug 21 Sat 2021
| 12:05 PM | ||||
| 913 | Minnesota TwinsK. Maeda -R | +196 | O 9 +100 | |
| 914 | New York YankeesG. Cole -R | -215 | U 9 -120 |
| 12:10 PM | ||||
| 915 | Chicago White SoxD. Keuchel -L | +125 | O 9 -120 | |
| 916 | Tampa Bay RaysL. Patino -R | -135 | U 9 +100 |
| 2:07 PM | ||||
| 917 | Detroit TigersW. Peralta -R | +233 | O 9½ -115 | |
| 918 | Toronto Blue JaysH. Ryu -L | -260 | U 9½ -105 |
| 3:05 PM | ||||
| 901 | New York MetsR. Hill -L | +237 | O 8½ -120 | |
| 902 | Los Angeles DodgersM. Scherzer -R | -265 | U 8½ +100 |
| 3:05 PM | ||||
| 903 | Washington NationalsP. Espino -R | +184 | O 9 -125 | |
| 904 | Milwaukee BrewersE. Lauer -L | -201 | U 9 +105 |
| 3:07 PM | ||||
| 927 | San Francisco GiantsK. Gausman -R | -130 | O 8½ -105 | |
| 928 | Oakland AthleticsS. Manaea -L | +120 | U 8½ -115 |
| 3:10 PM | ||||
| 919 | Los Angeles AngelsR. Detmers -L | +130 | O 9½ -120 | |
| 920 | Cleveland IndiansT. McKenzie -R | -141 | U 9½ +100 |
| 3:10 PM | ||||
| 921 | Seattle MarinersL. Gilbert -R | +161 | O 9 -110 | |
| 922 | Houston AstrosJ. Odorizzi -R | -175 | U 9 -110 |
| 6:05 PM | ||||
| 929 | Atlanta BravesD. Smyly -L | -205 | O 10½ -115 | |
| 930 | Baltimore OriolesM. Harvey -R | +188 | U 10½ -105 |
| 6:10 PM | ||||
| 923 | Texas RangersJ. Lyles -R | +279 | O 9½ -110 | |
| 924 | Boston Red SoxE. Rodriguez -L | -315 | U 9½ -110 |
| 6:15 PM | ||||
| 907 | Pittsburgh PiratesD. Peters -L | +170 | O 9 -115 | |
| 908 | St. Louis CardinalsJ. Happ -L | -185 | U 9 -105 |
| 7:10 PM | ||||
| 909 | Arizona DiamondbacksZ. Gallen -R | +152 | O 11½ -115 | |
| 910 | Colorado RockiesK. Freeland -L | -165 | U 11½ -105 |
| 7:40 PM | ||||
| 911 | Philadelphia PhilliesA. Nola -R | +170 | O 8 -115 | |
| 912 | San Diego PadresJ. Musgrove -R | -185 | U 8 -105 |
