Jul 31 Sat 2021
| 3:07 PM | ||||
| 963 | Kansas City RoyalsM. Minor -L | +179 | O 10½ +100 | |
| 964 | Toronto Blue JaysA. Manoah -R | -195 | U 10½ -120 |
| 4:05 PM | ||||
| 965 | Oakland AthleticsC. Irvin -L | -115 | O 9½ -110 | |
| 966 | Los Angeles AngelsJ. Barria -R | +105 | U 9½ -110 |
| 4:05 PM | ||||
| 975 | Houston AstrosZ. Greinke -R | -120 | O 8 -120 | |
| 976 | San Francisco GiantsA. Wood -L | +110 | U 8 +100 |
| 6:10 PM | ||||
| 967 | Boston Red SoxN. Eovaldi -R | -113 | O 8½ +100 | |
| 968 | Tampa Bay RaysR. Yarbrough -L | +103 | U 8½ -120 |
| 6:10 PM | ||||
| 969 | Baltimore OriolesJ. Means -L | -110 | O 9 -105 | |
| 970 | Detroit TigersM. Manning -R | +100 | U 9 -115 |
| 7:05 PM | ||||
| 953 | Philadelphia PhilliesA. Nola -R | -151 | O 8 -120 | |
| 954 | Pittsburgh PiratesJ. Brubaker -R | +139 | U 8 +100 |
| 7:10 PM | ||||
| 955 | Cincinnati RedsW. Miley -L | +112 | O 8 -115 | |
| 956 | New York MetsR. Hill -L | -122 | U 8 -105 |
| 7:10 PM | ||||
| 973 | Cleveland IndiansT. McKenzie -R | +161 | O 9 -120 | |
| 974 | Chicago White SoxD. Keuchel -L | -175 | U 9 +100 |
| 7:20 PM | ||||
| 957 | Milwaukee BrewersB. Woodruff -R | -151 | O 8½ -117 | |
| 958 | Atlanta BravesK. Muller -L | +139 | U 8½ -103 |
| 8:40 PM | ||||
| 961 | Colorado RockiesG. Marquez -R | +200 | O 7 -115 | |
| 962 | San Diego PadresY. Darvish -R | -220 | U 7 -105 |
