Jul 10 Sat 2021
| 4:05 PM | ||||
| 951 | Washington NationalsJ. Lester -L | +166 | O 9 -105 | |
| 952 | San Francisco GiantsA. Desclafani -R | -180 | U 9 -115 |
| 4:05 PM | ||||
| 969 | Oakland AthleticsJ. Kaprielian -R | -140 | O 9 -120 | |
| 970 | Texas RangersM. Foltynewicz -R | +130 | U 9 +100 |
| 4:05 PM | ||||
| 971 | Chicago White SoxL. Giolito -R | -190 | O 10 -115 | |
| 972 | Baltimore OriolesT. Eshelman -R | +175 | U 10 -105 |
| 4:10 PM | ||||
| 953 | Pittsburgh Pirates - Game #1T. Anderson -L | +175 | O 6 +105 | |
| 954 | New York Mets - Game #1 M. Stroman -R | -190 | U 6 -125 |
| 4:10 PM | ||||
| 955 | Atlanta BravesM. Fried -L | -110 | O 7 -115 | |
| 956 | Miami MarlinsT. Rogers -L | +100 | U 7 -105 |
| 4:10 PM | ||||
| 979 | Philadelphia PhilliesM. Moore -L | +125 | O 11 -110 | |
| 980 | Boston Red SoxM. Perez -L | -135 | U 11 -110 |
| 6:10 PM | ||||
| 973 | Kansas City RoyalsM. Minor -L | +110 | O 9 -110 | |
| 974 | Cleveland IndiansC. Quantrill -R | -120 | U 9 -110 |
| 7:15 PM | ||||
| 959 | Cincinnati RedsV. Gutierrez -R | +175 | O 8 -115 | |
| 960 | Milwaukee BrewersF. Peralta -R | -190 | U 8 -105 |
| 7:15 PM | ||||
| 975 | New York YankeesG. Cole -R | -110 | O 8½ +100 | |
| 976 | Houston AstrosZ. Greinke -R | +100 | U 8½ -120 |
| 10:10 PM | ||||
| 961 | Arizona DiamondbacksC. Smith -L | +233 | O 7½ -110 | |
| 962 | Los Angeles DodgersW. Buehler -R | -260 | U 7½ -110 |
| 10:10 PM | ||||
| 963 | Colorado RockiesG. Marquez -R | +148 | O 7 -115 | |
| 964 | San Diego PadresJ. Musgrove -R | -160 | U 7 -105 |
| 10:10 PM | ||||
| 977 | Los Angeles AngelsP. Sandoval -L | -115 | O 8½ -110 | |
| 978 | Seattle MarinersC. Flexen -R | +105 | U 8½ -110 |
