Aug 27 Fri 2021
Aug 28 Sat 2021
Aug 29 Sun 2021
| 6:00 PM | ||||
| 103 | Indianapolis Colts | -3½ -110 | O 33 -110 | |
| 104 | Detroit Lions | +3½ -110 | U 33 -110 |
| 6:30 PM | ||||
| 105 | Philadelphia Eagles | +4 -110 | O 33½ -110 | |
| 106 | New York Jets | -4 -110 | U 33½ -110 |
| 6:30 PM | ||||
| 107 | Pittsburgh Steelers | +3 -120 | O 36 -110 | |
| 108 | Carolina Panthers | -3 +100 | U 36 -110 |
| 7:00 PM | ||||
| 109 | Minnesota Vikings | +3½ +105 | O 38 -110 | |
| 110 | Kansas City Chiefs | -3½ -125 | U 38 -110 |
| 12:00 PM | ||||
| 111 | Green Bay Packers | +7½ -103 | O 35 -115 | |
| 112 | Buffalo Bills | -7½ -117 | U 35 -105 |
| 5:00 PM | ||||
| 113 | Baltimore Ravens | -3½ -120 | O 32 -115 | |
| 114 | Washington Football Team | +3½ +100 | U 32 -105 |
| 6:00 PM | ||||
| 115 | Chicago Bears | -1 -115 | O 35½ -110 | |
| 116 | Tennessee Titans | +1 -105 | U 35½ -110 |
| 7:00 PM | ||||
| 117 | Tampa Bay Buccaneers | -3½ -115 | O 36½ -110 | |
| 118 | Houston Texans | +3½ -105 | U 36½ -110 |
| 7:00 PM | ||||
| 119 | Arizona Cardinals | +3½ -117 | O 34½ -110 | |
| 120 | New Orleans Saints | -3½ -103 | U 34½ -110 |
| 8:05 PM | ||||
| 121 | Los Angeles Rams | +8½ -105 | O 33½ -110 | |
| 122 | Denver Broncos | -8½ -115 | U 33½ -110 |
| 9:00 PM | ||||
| 123 | Los Angeles Chargers | +6 -110 | O 34½ -110 | |
| 124 | Seattle Seahawks | -6 -110 | U 34½ -110 |
| 12:00 PM | ||||
| 125 | Jacksonville Jaguars | -3 -115 | O 36½ -110 | |
| 126 | Dallas Cowboys | +3 -105 | U 36½ -110 |
| 3:00 PM | ||||
| 127 | Miami Dolphins | -2 -110 | O 36 -112 | |
| 128 | Cincinnati Bengals | +2 -110 | U 36 -108 |
| 3:00 PM | ||||
| 129 | Las Vegas Raiders | +3½ -110 | O 35½ -110 | |
| 130 | San Francisco 49ers | -3½ -110 | U 35½ -110 |
| 5:00 PM | ||||
| 131 | New England Patriots | -3½ +100 | O 35 -105 | |
| 132 | New York Giants | +3½ -120 | U 35 -115 |
| 7:00 PM | ||||
| 133 | Cleveland Browns | -5½ -115 | O 36 -110 | |
| 134 | Atlanta Falcons | +5½ -105 | U 36 -110 |