Sep 19 Mon 2022
| 12:10 PM | ||||
| 961 | Minnesota TwinsS. Gray -R | +1½ -220 | -103 | O 7½ +100 |
| 962 | Cleveland GuardiansC. Quantrill -R | -1½ +190 | -107 | U 7½ -120 |
| 03:07 PM | ||||
| 963 | Seattle MarinersL. Gilbert -R | -1½ +115 | -135 | O 8 +100 |
| 964 | Los Angeles AngelsJ. Suarez -L | +1½ -135 | +125 | U 8 -120 |
| 05:40 PM | ||||
| 951 | Chicago CubsW. Miley -L | +1½ -175 | +129 | O 7 -110 |
| 952 | Miami MarlinsE. Cabrera -R | -1½ +155 | -139 | U 7 -110 |
| 05:40 PM | ||||
| 965 | Houston AstrosL. Garcia -R | +1½ -220 | +108 | O 7 -105 |
| 966 | Tampa Bay RaysD. Rasmussen -R | -1½ +190 | -118 | U 7 -115 |
| 06:05 PM | ||||
| 967 | Detroit TigersT. Alexander -L | +1½ -130 | +170 | O 8 -115 |
| 968 | Baltimore OriolesT. Wells -R | -1½ +110 | -185 | U 8 -105 |
| 06:20 PM | ||||
| 953 | Washington NationalsC. Abbott -R | +1½ +135 | +287 | O 8½ -110 |
| 954 | Atlanta BravesK. Wright -R | -1½ -155 | -325 | U 8½ -110 |
| 06:40 PM | ||||
| 955 | New York MetsM. Scherzer -R | -1½ +160 | -104 | O 7 -110 |
| 956 | Milwaukee BrewersC. Burnes -R | +1½ -180 | -106 | U 7 -110 |
| 07:40 PM | ||||
| 957 | San Francisco GiantsJ. Junis -R | -1½ +125 | -117 | O 11½ -102 |
| 958 | Colorado RockiesC. Kuhl -R | +1½ -145 | +107 | U 11½ -118 |
