Apr 25 Mon 2022
| 05:45 PM | ||||
| 953 | Colorado RockiesK. Freeland -L | +1½ -125 | +172 | O 8½ -110 |
| 954 | Philadelphia PhilliesK. Gibson -R | -1½ +105 | -187 | U 8½ -110 |
| 06:07 PM | ||||
| 959 | Boston Red SoxN. Eovaldi -R | +1½ -180 | +118 | O 8½ +105 |
| 960 | Toronto Blue JaysJ. Berrios -R | -1½ +160 | -128 | U 8½ -125 |
| 06:45 PM | ||||
| 955 | New York MetsM. Scherzer -R | -1½ +120 | -145 | O 7 +100 |
| 956 | St. Louis CardinalsM. Mikolas -R | +1½ -140 | +134 | U 7 -120 |
| 07:05 PM | ||||
| 961 | Houston AstrosF. Valdez -L | -1½ +120 | -133 | O 8 -125 |
| 962 | Texas RangersD. Dunning -R | +1½ -140 | +123 | U 8 +105 |
| 08:38 PM | ||||
| 963 | Cleveland GuardiansS. Bieber -R | -1½ +135 | -115 | O 8 -110 |
| 964 | Los Angeles AngelsM. Lorenzen -R+1 Markets | +1½ -155 | +105 | U 8 -110 |
| 08:40 PM | ||||
| 957 | Los Angeles DodgersW. Buehler -R | -1½ -125 | -190 | O 8½ -110 |
| 958 | Arizona DiamondbacksM. Kelly -R | +1½ +105 | +175 | U 8½ -110 |
