Apr 18 Mon 2022
| 10:10 AM | ||||
| 913 | Minnesota TwinsD. Bundy -R | +1½ -160 | +125 | O 9 -120 |
| 914 | Boston Red SoxR. Hill -L+1 Markets | -1½ +140 | -135 | U 9 +100 |
| 05:10 PM | ||||
| 915 | Chicago White SoxD. Keuchel -L | +1½ -210 | -105 | O 7½ -125 |
| 916 | Cleveland GuardiansT. McKenzie -R+1 Markets | -1½ +180 | -105 | U 7½ +105 |
| 06:05 PM | ||||
| 901 | Arizona DiamondbacksM. Bumgarner -L | +1½ -170 | +126 | O 8 -130 |
| 902 | Washington NationalsJ. Gray -R+1 Markets | -1½ +150 | -136 | U 8 +110 |
| 06:10 PM | ||||
| 903 | San Francisco GiantsA. Cobb -R | +1½ -195 | +111 | O 6½ -120 |
| 904 | New York MetsT. Megill -R+1 Markets | -1½ +170 | -121 | U 6½ +100 |
| 06:40 PM | ||||
| 905 | Pittsburgh PiratesZ. Thompson -R | +1½ -130 | +157 | O 8½ -105 |
| 906 | Milwaukee BrewersE. Lauer -L+1 Markets | -1½ +110 | -170 | U 8½ -115 |
| 07:10 PM | ||||
| 917 | Los Angeles AngelsM. Lorenzen -R | +1½ -155 | +136 | O 9 -105 |
| 918 | Houston AstrosL. Garcia -R+1 Markets | -1½ +135 | -147 | U 9 -115 |
| 07:40 PM | ||||
| 907 | Philadelphia PhilliesA. Nola -R | -1½ -110 | -155 | O 11 -105 |
| 908 | Colorado RockiesC. Kuhl -R+1 Markets | +1½ -110 | +143 | U 11 -115 |
| 08:40 PM | ||||
| 909 | Cincinnati RedsN. Lodolo -L | +1½ -140 | +148 | O 7½ -110 |
| 910 | San Diego PadresS. Manaea -L+1 Markets | -1½ +120 | -160 | U 7½ -110 |
| 08:40 PM | ||||
| 919 | Baltimore OriolesS. Watkins -R | +1½ -135 | +167 | O 8 -105 |
| 920 | Oakland AthleticsF. Montas -R+1 Markets | -1½ +115 | -182 | U 8 -115 |
| 09:10 PM | ||||
| 911 | Atlanta BravesH. Ynoa -R | +1½ -120 | +170 | O 8 -110 |
| 912 | Los Angeles DodgersC. Kershaw -L+1 Markets | -1½ +100 | -185 | U 8 -110 |
