May 20 Fri 2022
| 06:35 PM | ||||
| 903 | St. Louis CardinalsA. Wainwright -R | -1½ +105 | -147 | O 8 -115 |
| 904 | Pittsburgh PiratesZ. Thompson -R | +1½ -125 | +136 | U 8 -105 |
| 06:40 PM | ||||
| 905 | Atlanta BravesC. Morton -R | -1½ +135 | -120 | O 7½ +100 |
| 906 | Miami MarlinsT. Rogers -L | +1½ -155 | +110 | U 7½ -120 |
| 07:05 PM | ||||
| 907 | Los Angeles DodgersJ. Urias -L | -1½ +110 | -138 | O 9 +100 |
| 908 | Philadelphia PhilliesR. Suarez -L | +1½ -130 | +128 | U 9 -120 |
| 07:05 PM | ||||
| 915 | Tampa Bay RaysJ. Beeks -L | -1½ +110 | -144 | O 8½ +105 |
| 916 | Baltimore OriolesT. Wells -R | +1½ -130 | +133 | U 8½ -125 |
| 07:05 PM | ||||
| 917 | Chicago White SoxD. Keuchel -L | +1½ -115 | +170 | O 8 -125 |
| 918 | New York YankeesN. Cortes -L | -1½ -105 | -185 | U 8 +105 |
| 07:07 PM | ||||
| 929 | Cincinnati RedsL. Castillo -R | +166 | O 8½ +105 | |
| 930 | Toronto Blue JaysH. Ryu -L | -181 | U 8½ -125 |
| 07:10 PM | ||||
| 919 | Detroit TigersT. Skubal -L | -108 | O 8½ -110 | |
| 920 | Cleveland GuardiansA. Civale -R+1 Markets | -102 | U 8½ -110 |
| 08:10 PM | ||||
| 909 | Washington NationalsE. Fedde -R | +1½ -125 | +164 | O 8½ +105 |
| 910 | Milwaukee BrewersE. Lauer -L | -1½ +105 | -178 | U 8½ -125 |
| 08:10 PM | ||||
| 923 | Minnesota TwinsD. Smeltzer -R | -126 | O 8½ -110 | |
| 924 | Kansas City RoyalsD. Lynch -L | +116 | U 8½ -110 |
| 08:10 PM | ||||
| 925 | Texas RangersM. Perez -L | +146 | O 8 -115 | |
| 926 | Houston AstrosC. Javier -R | -158 | U 8 -105 |
| 08:40 PM | ||||
| 911 | New York MetsC. Carrasco -R | -1½ +115 | -130 | O 10 -120 |
| 912 | Colorado RockiesG. Marquez -R | +1½ -135 | +120 | U 10 +100 |
| 09:38 PM | ||||
| 927 | Oakland AthleticsP. Blackburn -R | +146 | O 8 -110 | |
| 928 | Los Angeles AngelsC. Silseth -R | -158 | U 8 -110 |
| 10:15 PM | ||||
| 913 | San Diego PadresS. Manaea -L | +1½ -215 | -101 | O 7½ -115 |
| 914 | San Francisco GiantsJ. Junis -R | -1½ +185 | -109 | U 7½ -105 |