Aug 27 Fri 2021
| 6:05 PM | ||||
| 901 | Arizona DiamondbacksT. Widener -R | +192 | O 8½ -119 | |
| 902 | Philadelphia PhilliesA. Nola -R | -210 | U 8½ -101 |
| 6:05 PM | ||||
| 903 | St. Louis CardinalsJ. Happ -L | -153 | O 9 -115 | |
| 904 | Pittsburgh PiratesD. Peters -L | +141 | U 9 -105 |
| 6:05 PM | ||||
| 913 | Tampa Bay RaysS. McClanahan -L | -218 | O 10½ -115 | |
| 914 | Baltimore OriolesM. Harvey -R | +198 | U 10½ -105 |
| 6:10 PM | ||||
| 907 | Cincinnati RedsW. Miley -L | -145 | O 8 -105 | |
| 908 | Miami MarlinsZ. Thompson -R | +134 | U 8 -115 |
| 6:10 PM | ||||
| 917 | Toronto Blue JaysS. Matz -L | -143 | O 9½ -110 | |
| 918 | Detroit TigersM. Manning -R | +132 | U 9½ -110 |
| 7:10 PM | ||||
| 925 | Milwaukee BrewersE. Lauer -L | -135 | O 9½ -120 | |
| 926 | Minnesota TwinsA. Albers -L | +125 | U 9½ +100 |
| 7:10 PM | ||||
| 927 | Chicago CubsK. Thompson -R | +198 | O 9½ +100 | |
| 928 | Chicago White SoxD. Keuchel -L | -218 | U 9½ -120 |
| 8:40 PM | ||||
| 921 | New York YankeesG. Cole -R | -141 | O 7½ -115 | |
| 922 | Oakland AthleticsS. Manaea -L | +130 | U 7½ -105 |
