Jun 25 Fri 2021
| 4:10 PM | ||||
| 901 | Colorado RockiesJ. Gray -R | +200 | O 7½ -115 | |
| 902 | Milwaukee BrewersC. Burnes -R | -220 | U 7½ -105 |
| 7:07 PM | ||||
| 917 | Baltimore OriolesM. Harvey -R | +184 | O 11 -110 | |
| 918 | Toronto Blue JaysA. Manoah -R | -200 | U 11 -110 |
| 7:10 PM | ||||
| 907 | Washington NationalsJ. Lester -L | +115 | O 7½ -110 | |
| 908 | Miami MarlinsP. Lopez -R | -125 | U 7½ -110 |
| 7:10 PM | ||||
| 919 | Houston AstrosF. Valdez -L | -250 | O 9½ -105 | |
| 920 | Detroit TigersW. Peralta -R | +224 | U 9½ -115 |
| 7:10 PM | ||||
| 923 | New York YankeesD. German -R | -125 | O 10½ -105 | |
| 924 | Boston Red SoxM. Perez -L | +115 | U 10½ -115 |
| 8:05 PM | ||||
| 925 | Kansas City RoyalsM. Minor -L | -108 | O 8 -115 | |
| 926 | Texas RangersD. Dunning -R | -102 | U 8 -105 |
| 8:10 PM | ||||
| 927 | Cleveland IndiansC. Quantrill -R | +110 | O 9½ -105 | |
| 928 | Minnesota TwinsR. Dobnak -R | -120 | U 9½ -115 |
| 8:10 PM | ||||
| 929 | Seattle MarinersY. Kikuchi -L | +154 | O 8 +100 | |
| 930 | Chicago White SoxC. Rodon -L | -167 | U 8 -120 |
| 8:15 PM | ||||
| 911 | Pittsburgh PiratesW. Crowe -R | +148 | O 9 -105 | |
| 912 | St. Louis CardinalsK. Kim -L | -160 | U 9 -115 |
| 9:45 PM | ||||
| 931 | Oakland AthleticsS. Manaea -L | -108 | O 8½ +100 | |
| 932 | San Francisco GiantsJ. Cueto -R | -102 | U 8½ -120 |
| 10:10 PM | ||||
| 913 | Arizona DiamondbacksC. Martin -R | +228 | O 8½ -115 | |
| 914 | San Diego PadresC. Paddack -R | -255 | U 8½ -105 |
| 10:10 PM | ||||
| 915 | Chicago CubsJ. Arrieta -R | +148 | O 9 -105 | |
| 916 | Los Angeles DodgersT. Gonsolin -R | -160 | U 9 -115 |
