Jun 18 Fri 2021
| 7:05 PM | ||||
| 951 | New York MetsJ. Lucchesi -L | -108 | O 9 +105 | |
| 952 | Washington NationalsE. Fedde -R | -102 | U 9 -125 |
| 7:05 PM | ||||
| 979 | Cleveland IndiansJ. Mejia -R | -146 | O 8½ -120 | |
| 980 | Pittsburgh PiratesC. Kuhl -R | +135 | U 8½ +100 |
| 7:20 PM | ||||
| 953 | St. Louis CardinalsC. Martinez -R | +163 | O 9½ +100 | |
| 954 | Atlanta BravesM. Fried -L+1 Markets | -177 | U 9½ -120 |
| 8:05 PM | ||||
| 969 | Minnesota TwinsJ. Berrios -R | -157 | O 8½ -125 | |
| 970 | Texas RangersM. Foltynewicz -R | +145 | U 8½ +105 |
| 8:10 PM | ||||
| 973 | Chicago White SoxC. Rodon -L | -108 | O 8½ -120 | |
| 974 | Houston AstrosL. Garcia -R+1 Markets | -102 | U 8½ +100 |
| 8:40 PM | ||||
| 957 | Milwaukee BrewersC. Burnes -R | -185 | O 10½ -105 | |
| 958 | Colorado RockiesA. Senzatela -R+1 Markets | +170 | U 10½ -115 |
| 9:38 PM | ||||
| 975 | Detroit TigersJ. Urena -R | +172 | O 9 -125 | |
| 976 | Los Angeles AngelsA. Cobb -R+1 Markets | -187 | U 9 +105 |
| 9:45 PM | ||||
| 961 | Philadelphia PhilliesV. Velasquez -R | +110 | O 8½ +100 | |
| 962 | San Francisco GiantsJ. Cueto -R | -120 | U 8½ -120 |
| 10:10 PM | ||||
| 963 | Cincinnati RedsT. Santillan -R | +163 | O 8 -115 | |
| 964 | San Diego PadresC. Paddack -R+1 Markets | -177 | U 8 -105 |
